2,4-Difluorophenyl isocyanate → HCID 22105938, compound

Participants

Reaction Steps

A solution of 3-amino-4-(2-chlorophenyl)-1,7-naphthyridine (169 mg, 0.66 mmol) and 2,4-difluorophenylisocyanate (102 mg, 0.66 mmol) in tetrahydrofuran (50 ml) was refluxed for 8 hours. The mixture was concentrated, and the residue was purified by column chromatography (silica gel; methanol:chloroform=1:9), and recrystallized from hexane to give the title compound (98 mg, 0.24 mmol) as colorless powder.

Provenance & Evidence