Ammonium formate → HCID 22105965, compound

Participants

Reaction Steps

To a solution of N-[1-butyl-4-{3-(3-benzyloxypropoxy)phenyl}-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea (316 mg, 0.48 mmol) in methanol (20 ml) were added ammonium formate (91 mg, 1.44 mmol) and 10% palladium-carbon (100 mg), and the mixture was refluxed for 10 hours. After allowed to stand for cooling, the mixture was filtered through a cerite pad, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, and the mixture was washed with water, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The residue was concentrated under reduced pressure, purified by silica gel column chromatography (1-3% methanol in chloroform), and crystallized from ether/hexane to give the title compound (85 mg, 0.15 mmol).

Provenance & Evidence