Acetic Anhydride → HCID 22106370, compound

HRID 1456382Notes

Reaction equation

HRID 1456382 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][N:13]=2)[C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)=[C:7]([NH:23][C:24]([NH:26][C:27]2[C:32]([CH:33]([CH3:35])[CH3:34])=[CH:31][CH:30]=[CH:29][C:28]=2[CH:36]([CH3:38])[CH3:37])=[O:25])[C:6]1=[O:39].[C:40](OC(=O)C)(=[O:42])[CH3:41]>N1C=CC=CC=1>[C:40]([NH:1][CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][N:13]=2)[C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)=[C:7]([NH:23][C:24]([NH:26][C:27]2[C:32]([CH:33]([CH3:35])[CH3:34])=[CH:31][CH:30]=[CH:29][C:28]=2[CH:36]([CH3:38])[CH3:37])=[O:25])[C:6]1=[O:39])(=[O:42])[CH3:41]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22106124HCID 22106124, compound

Product 1

HCID 22106370HCID 22106370, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-[1-(3-Aminopropyl)-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea (50 mg, 0.1 mmol) was dissolved in pyridine (1 ml), and thereto was added acetic anhydride (0.5 ml). The mixture was stirred for 40 minutes, and concentrated under reduced pressure. The residue was purified by preparative thin layer chromatography to give the title compound (49 mg, 0.09 mmol).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was purified by preparative thin layer chromatography

Sources & evidence

ORD record
ord-459e8b865c4547419baa41f06cc9f229
Source dataset
uspto-grants-1998_12
Patent number
US05843957

Reaction notes

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