Hydrogen Peroxide → HCID 22106390, compound

Participants

Reaction Steps

To a solution of N-[1-(3-cyanopropyl)-4-(3-methoxyphenyl)-l,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea (100 mg, 0.19 mmol) in methanol-acetone (3 ml) were added 10% aqueous sodium carbonate solution (1 ml) and 30% hydrogen peroxide (1 ml), and the mixture was stirred at room temperature for three hours. The mixture was poured into water, and extracted with ethyl acetate. The extract was washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The residue was concentrated under reduced pressure, and purified by preparative thin layer chromatography to give the title compound (96 mg, 0.17 mmol).

Provenance & Evidence