Ammonium formate → HCID 22106111, compound

Participants

Reaction Steps

To a solution of N-[1-butyl-4-{3-(3-hydroxy-1-propynyl)phenyl}-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea (10 mg, 0.02 mmol) in methanol (3 ml) were added ammonium formate (5 mg, 0.08 mmol) and 10% palladium-carbon (5 mg), and the mixture was heated under reflux for five hours. After allowed to stand for cooling, the mixture was filtered through a cerite pad, and the filtrate was concentrated. The concentrated residue was diluted with ethyl acetate, and washed with water, washed with a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The residue was concentrated under reduced pressure, and further purified by thin layer chromatography (hexane:ethyl acetate=5:5) to give the title compound (6 mg, 0.02 mmol).

Provenance & Evidence