HCID 22106143, compound → HCID 67552825, compound

Participants

Reaction Steps

A suspension of N-[1-butyl-4-[3-{(4-diethylamino-2-butynyl)oxy}-phenyl]-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropylphenyl)urea (300 mg, 0.45 mmol), a Lindlar catalyst (distributed by Sigma Alderich Japan, 20 mg) in methanol (20 ml) was stirred at room temperature under hydrogen atmosphere for six hours. The mixture was filtered through a cerite pad, and the filtrate was concentrated under reduced pressure. The resultant was dissolved in chloroform, and the mixture was washed with a dilute aqueous ammonia, washed with water, washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (3-8% methanol in chloroform) to give the title compound (280 mg, 0.43 mmol).

Provenance & Evidence