Sodium sulfate decahydrate → HCID 67583583, compound

Participants

Reaction Steps

398 mg of (2R,4R)-1-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-[2-{4-fluoro-2-[2-(4-fluorophenyl)ethyl]phenoxy}ethyl]pyrrolidine [prepared as described in step (a) above] were dissolved in 10 ml of tetrahydrofiran, and the resulting solution was added dropwise to a suspension of 81 mg of lithium aluminum hydride in 10 ml of tetrahydrofuran, whilst ice-cooling and stirring. The resulting mixture was then heated under reflux for 1 hour. At the end of this time, the reaction mixture was cooled on ice, and sodium sulfate decahydrate was added in order to decompose any excess hydride. Insoluble substances were removed by filtration, and the filtrate was concentrated by evaporation under reduced pressure. The concentrate was then purified by silica gel column chromatography, using a 7:3 by volume mixture of methylene chloride and methanol as the eluent, to give 151 mg (yield 59%) of the title compound as a colorless oily substance.

Provenance & Evidence