Hydrochloric Acid → HCID 67583582, compound

Participants

Reaction Steps

138 mg of (2R,4R)-2-[2-{4-fluoro-2-[2-(4-fluorophenyl)ethyl]phenoxy}ethyl]-4-hydroxy-1-methylpyrrolidine [prepared as described in step (b) above] were dissolved in 4 ml of ethyl acetate, and then 0.15 ml of a 4N solution of hydrogen chloride in ethyl acetate was added to the resulting solution, and the solution was concentrated by evaporation under reduced pressure. The resulting oily substance was dissolved in 5 ml of ethyl acetate, and the resulting solution was allowed to stand at room temperature for about 10 minutes. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 66 mg (yield 43%) of the title compound as colorless crystals, melting at 70°-73° C.

Provenance & Evidence