4-Fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenol → HCID 67584131, compound

Participants

Reaction Steps

622 mg of 4-fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenol (prepared as described in Preparation 5) were dissolved in 7 ml of N,N-dimethylacetamide. The resulting solution was allowed to react with 343 mg of potassium t-butoxide and 678 mg of (2S,4R)-2-(2-chloroethyl)-1-ethoxycarbonyl-4-hydroxypyrrolidine and extracted in the same manner as described in step (a) of Example 1. The resulting oily substance was purified by silica gel column chromatography, using a 2:3 by volume mixture of hexane and ethyl acetate as the eluent, to give 552 mg (yield 52%) of the title compound as a colorless oily substance.

Provenance & Evidence