Aluminium lithium hydride → HCID 67583627, compound

Participants

Reaction Steps

551 mg of (2R,4R)-1-ethoxycarbonyl-2-[2-{4-fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenoxy}ethyl]-4-hydroxypyrrolidine [prepared as described in step (a) above], 20 ml of tetrahydrofuran and 140 mg of lithium aluminum hydride were allowed to react together and subsequently treated in the same manner as described in step (b) of Example 1. The concentrate thus obtained was purified by silica gel column chromatography, using a 3:2 by volume mixture of methylene chloride and methanol as the eluent, to give 405 mg (yield 84%) of the title compound as a colorless oily substance.

Provenance & Evidence