Hydrochloric Acid → HCID 67584014, compound

Participants

Reaction Steps

399 mg of the (2R,4R)-2-[2-{4-fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenoxy}ethyl]-4-hydroxy-1-methylpyrrolidine [prepared as described in step (b) above] were dissolved in 5 ml of ethyl acetate. Addition of 0.38 ml of a 4N solution of hydrogen chloride in ethyl acetate resulted in the precipitation of crystals. The solvent was removed by evaporation under reduced pressure, and the resulting solid substance was dissolved in a small quantity (approximately 0.5 ml) of methylene chloride and then 5 ml of ethyl acetate were added to the resulting solution. The resulting mixture was then allowed to stand at room temperature for about 10 minutes. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 359 mg (yield 82%) of the title compound as colorless crystals, melting at 128-130° C.

Provenance & Evidence