4-Fluoro-2-(2-phenylethyl)phenol → HCID 53877636, compound

Participants

Reaction Steps

1090 mg of 4-fluoro-2-(2-phenylethyl)phenol (prepared as described in Preparation 3), 1870 mg of (2S,4R)-2-(2-bromoethyl)-1-t-butoxycarbonyl-4-t-butyldimethylsilyloxypyrrolidine and 566 mg of potassium t-butoxide were allowed to react together in 10 ml of N,N-dimethylacetamide, and the resulting mixture was extracted in the same manner as described in step (a) of Example 2. The resulting oily substance was purified by silica gel column chromatography, using a 5:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2090 mg (yield 84%) of the title compound as a colorless oily substance.

Provenance & Evidence