Tetrabutylammonium Fluoride → HCID 54502309, compound

Participants

Reaction Steps

1490 mg of (2R,4R)-1-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-{2-[4-fluoro-2-(2-phenylethyl)phenoxy]ethyl}pyrrolidine [prepared as described in Example 5(a)] were dissolved in 15 ml of tetrahydrofuran, and then 0.79 ml of tetrabutylammonium fluoride were added to the resulting solution. The resulting mixture was then stirred at room temperature for 0.5 hours. At the end of this time, the reaction solution was concentrated by evaporation under reduced pressure, and the resulting concentrated oily substance was purified by silica gel column chromatography, using a 1:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 1115 mg (yield 95%) of the title compound as a colorless solid substance.

Provenance & Evidence