Aluminium lithium hydride → HCID 54563963, compound

Participants

Reaction Steps

1115 mg of (2R,4R)-1-t-butoxycarbonyl-2-{2-[4-fluoro-2-(2-phenylethyl)-phenoxy]ethyl}-4-hydroxypyrrolidine [prepared as described in step (a) above], 20 ml of tetrahydrofuran and 200 mg of lithium aluminum hydride were allowed to react together and subsequently treated in the same manner as described in step (b) of Example 1. The concentrated substance thus obtained was purified by silica gel column chromatography, using a 5:1 by volume mixture of methylene chloride and methanol as the eluent, to give 540 mg (yield 61%) of the title compound as a colorless solid substance.

Provenance & Evidence