2-[2-(3,4-Difluorophenyl)ethyl]-4-fluorophenol → HCID 67584773, compound

Participants

Reaction Steps

400 mg of 2-[2-(3,4-difluorophenyl)ethyl]-4-fluorophenol (prepared as described in Preparation 7), 690 mg of (2S,4R)-2-(2-bromoethyl)-1-t-butoxycarbonyl-4-t-butyldimethylsilyloxypyrrolidine and 208 mg of potassium t-butoxide were allowed to react together in 5 ml of N,N-dimethylacetamide and extracted in the same manner as described in step (a) of Example 2. The resulting oily substance was purified by silica gel column chromatography, using a 5:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 580 mg (yield 63%) of the title compound as a colorless oily substance.

Provenance & Evidence