Aluminium lithium hydride → HCID 67583567, compound

Participants

Reaction Steps

280 mg of (2R,4R)-1-t-butoxycarbonyl-2-[2-{2-[2-(3,4-difluorophenyl)-ethyl]-4-fluorophenoxy}ethyl]-4-hydroxypyrrolidine [prepared as described in step (b) above], 5 ml of tetrahydrofuran and 50 mg of lithium aluminum hydride were allowed to react together and subsequently treated in the same manner as described in step (b) of Example 1. The concentrated substance thus obtained was purified by silica gel column chromatography, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 140 mg (yield 63%) of the title compound as a colorless solid substance.

Provenance & Evidence