HCID 15007720, compound → HCID 54296142, compound

Participants

Reaction Steps

500 mg of 4-chloro-2-(2-phenylethyl)phenol were dissolved in 10 ml of N,N-dimethylacetamide, allowed to react with 270 mg of potassium t-butoxide and 520 mg of (2S,4R)-2-(2-chloroethyl)-1-ethoxycarbonyl-4-hydroxypyrrolidine and extracted in the same manner as described in step (a) of Example 1. The resulting oily substance was purified by silica gel column chromatography, using a 1:2 by volume mixture of hexane and ethyl acetate as the eluent, to give 260 mg (yield 29%) of the title compound as an oily substance.

Provenance & Evidence