Aluminium lithium hydride → HCID 54185493, compound

Participants

Reaction Steps

260 mg of (2R,4R)-2-{2-[4-chloro-2-(2-phenylethyl)phenoxy]ethyl}-1-ethoxycarbonyl-4-hydroxypyrrolidine [prepared as described in step (a) above], 10 ml of tetrahydrofuran and 70 mg of lithium aluminum hydride were allowed to react together and subsequently treated in the same manner as described in step (b) of Example 1. The concentrated substance thus obtained was purified by silica gel column chromatography, using a 5:1 by volume mixture of methylene chloride and methanol as the eluent, to give 103 mg (yield 46%) of the title compound as a colorless solid substance, melting at 65°-68° C.

Provenance & Evidence