HCID 14531142, compound → HCID 54078194, compound

Participants

Reaction Steps

1130 mg of 4-methoxy-2-(2-phenylethyl)phenol were dissolved in 10 ml of N,N-dimethylacetamide, allowed to react with 610 mg of potassium t-butoxide and 1000 mg of (2S,4R)-2-(2-chloroethyl)-1-ethoxycarbonyl-4-hydroxypyrrolidine and extracted in the same manner as described in step (a) of Example 2. The resulting oily substance was purified by silica gel column chromatography, using a 1:2 by volume mixture of hexane and ethyl acetate as the eluent, to give 448 mg (yield 24%) of the title compound as an oily substance.

Provenance & Evidence