Aluminium lithium hydride → HCID 54220910, compound

Participants

Reaction Steps

1500 mg of (2R,4R)-4-dimethylcarbamoyloxy-2-{2-[5-methoxy-2-(2-phenylethyl)phenoxy]ethyl}-1-octyloxycarbonylpyrrolidine [prepared as described in step (a) above], 25 ml of tetrahydrofuran and 310 mg of lithium aluminum hydride were allowed to react together and subsequently treated in the same manner as described in step (b) of Example 1. The concentrated substance thus obtained was purified by silica gel column chromatography, using a 5:1 by volume mixture of methylene chloride and methanol as the eluent, to give 385 mg (yield 41%) of the title compound as a colorless solid substance.

Provenance & Evidence