HCID 22106913, compound → HCID 53949785, compound

Participants

Reaction Steps

680 mg of 5-chloro-2-(2-phenylethyl)phenol (prepared as described in Preparation 9) were dissolved in 10 ml of N,N-dimethylacetamide, allowed to react with 360 mg of potassium t-butoxide and 1000 mg of (2S,4R)-2-(2-chloroethyl)-4-dimethylcarbamoyloxy-1-octyloxycarbonylpyrrolidine and extracted in the same manner as described in step (a) of Example 2. The resulting oily substance was purified by silica gel column chromatography, using a 1:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 1 .38 g (yield 91%) of the title compound as an oily substance.

Provenance & Evidence