Hydrochloric Acid → HCID 67583603, compound

Participants

Reaction Steps

256 mg of (2R,4R)-2-{2-[5-chloro-2-(2-phenylethyl)phenoxy]ethyl}-4-hydroxy-1-methylpyrrolidine [prepared as described in step (b) above] were dissolved in 5 ml of ethyl acetate, and then 0.18 ml of a 4N solution of hydrogen chloride in ethyl acetate was added to the resulting solution. The solvent was then removed by evaporation under reduced pressure. The resulting oily substance was dissolved in 10 ml of ethyl acetate, and allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 183 mg (yield 65%) of the title compound as colorless crystals, melting at 99°-102° C.

Provenance & Evidence