HCID 22106941, compound → HCID 54165020, compound

Participants

Reaction Steps

520 mg of 6-fluoro-2-(2-phenylethyl)phenol (prepared as described in Preparation 10) were dissolved in 10 ml of N,N-dimethylacetamide, allowed to react with 300 mg of potassium t-butoxide and 820 mg of (2S,4R)-2-(2-chloroethyl)-4-dimethylcarbamoyloxy-1-octyloxycarbonylpyrrolidine and extracted in the same manner as described in step (a) of Example 2. The resulting oily substance was purified by silica gel column chromatography, using a 2:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 984 mg (yield 81 %) of the title compound as an oily substance.

Provenance & Evidence