Aluminium lithium hydride → HCID 53666918, compound

Participants

Reaction Steps

984 mg of (2R,4R)-4-dimethylcarbamoyloxy-2-{2-[6-fluoro-2-(2-phenylethyl)phenoxy]ethyl}-1-octyloxycarbonylpyrrolidine [prepared as described in step (a) above], 20 ml of tetrahydrofuran and 200 mg of lithium aluminum hydride were allowed to react together and subsequently treated in the same manner as described in step (b) of Example 1. The concentrated substance thus obtained was purified by silica gel column chromatography, using a 5:1 by volume mixture of methylene chloride and methanol as the eluent, to give 319 mg (yield 53%) of the title compound as an oily substance.

Provenance & Evidence