Hydrochloric Acid → HCID 67583577, compound

Participants

Reaction Steps

319 mg of (2R,4R)-2-{2-[6-fluoro-2-(2-phenylethyl)phenoxy]ethyl}-4-hydroxy-1-methylpyrrolidine [prepared as described in step (b) above] were dissolved in 10 ml of ethyl acetate, and then 0.23 ml of a 4N solution of hydrogen chloride in ethyl acetate was added to the resulting solution. The solvent was then removed by evaporation under reduced pressure. The resulting oily substance was dissolved in ethyl acetate, and allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 320 mg (yield 91%) of the title compound as colorless crystals, melting at 136°-138° C.

Provenance & Evidence