Carbon Tetrachloride → HCID 22106943, compound

Participants

Reaction Steps

4.69 g of 4-chloro-2-methoxymethoxybenzyl alcohol [prepared as described in step (b) above] were dissolved in 80 ml of tetrahydrofuran, and then 7.11 g of carbon tetrachloride and 12.14 g of triphenylphosphine were added to the resulting solution. The resulting mixture was stirred at room temperature for 1 hour and then heated under reflux for 2.5 hours. At the end of this time, any insoluble substance was removed by filtration, and the filtrate was concentrated by evaporation under reduced pressure. The residue was purified by silica gel column chromatography, using a 10:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 3.38 g (yield 66%) of the title compound as an oily substance.

Provenance & Evidence