Trifluoroacetic acid → 3(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-(4-(2,6-dichlorophenyl)-oxazol-2-yl)-4-oxobutyric Acid

Participants

Reaction Steps

To a solution of compound 709 in CH2Cl2 (4.0 mL) was added TFA (2.0 mL) and the reaction stirred at rt for 1 hr. The reaction was concentrated in vacuo and the residue co-concentrated with toluene. Prep-HPLC provided 35 mg of compound 710: 1H NMR (500 MHz, CD3 OD) δ 8.90 (m), 8.52 (m), 8.35 (m), 7.83 (m), 7.62-7.39 (m), 7.38-7.16 (m), 5.52 (m), 5.01 (m), 5.01 (m), 4.99-4.53 (m), 4.42 (m), 4.33-3.82 (m), 3.16-2.93 (m), 2.91-2.48 (m), 2.24 (m), 1.09-0.85 (m). ##STR89##

Provenance & Evidence