反应详情

To a mixture of 2-Chloro-4-fluorophenol (25 g, 0.171 mol) in H2O (100 mL) and Et2O (300 mL) at 0° C. was added dropwise concentrated nitric acid (25 mL). After the addition was complete the reaction was warmed to rt and stirred for 3 hr. The layers were separated and the organic phase washed with 1:1 brine:H2O, brine, dried over MgSO4, filtered and concentrated in vacuo to a slurry. The slurry was diluted with hexane and the yellow solid collected and dried to provide 23.6 g of compound 711. ##STR90##

1. additionAfter the addition
2. customThe layers were separated
3. washthe organic phase washed with 1:1 brine
4. dry with materialH2O, brine, dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo to a slurry
7. additionThe slurry was diluted with hexane
8. customthe yellow solid collected
9. customdried