2,4-Dichloro-6-nitrophenol → 3(S)-(Allyloxycarbonyl)-amino-4-(4,6-dichorobenzoxazol-2-yl)-4-hydroxy-butyric Acid tert-Butyl Ester

HRID 1456657Notes

Reaction equation

HRID 1456657 reaction equation
[C:1]([O:5][C:6](=[O:29])[CH:7]([NH2:28])[C@H:8]([C:22]([O:24][CH2:25][CH:26]=[CH2:27])=[O:23])[CH:9]([C:11]1[O:12][C:13]2[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16](F)[C:14]=2[N:15]=1)[OH:10])([CH3:4])([CH3:3])[CH3:2].[Cl:30]C1C=C(F)C=C([N+]([O-])=O)C=1O.ClC1C=C(Cl)C=C([N+]([O-])=O)C=1O>>[C:1]([O:5][C:6](=[O:29])[CH:7]([NH2:28])[C@H:8]([C:22]([O:24][CH2:25][CH:26]=[CH2:27])=[O:23])[CH:9]([C:11]1[O:12][C:13]2[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:30])[C:14]=2[N:15]=1)[OH:10])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 118712,4-Dichloro-6-nitrophenolHCID 37278862-Chloro-4-fluoro-6-nitrophenolHCID 697258443(S)-(Allyloxycarbonyl)-amino-4-(6-chloro-4-fluorobenzoxazol-2-yl)-4-hydroxy-butyric Acid tert-Butyl Ester

Product 1

HCID 1317209653(S)-(Allyloxycarbonyl)-amino-4-(4,6-dichorobenzoxazol-2-yl)-4-hydroxy-butyric Acid tert-Butyl Ester

Procedure

Compound 718 was prepared by a similar method as that used for compound 714, except compound 711 was replaced with 2,4-dichloro-6-nitrophenol. ##STR97##

Sources & evidence

ORD record
ord-cfa314d1ce5148cd883cab96a09fc141
Source dataset
uspto-grants-1998_12
Patent number
US05843904

Reaction notes

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