3(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-(4-(2,6-dichlorophenyl)-oxazol-2-yl)-4-oxobutyric Acid → 3(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-(6-chloro-4-fluorobenzoxazol-2-yl)-4-oxobutyric Acid

Participants

Role	Name	HCID	Charge
Reactant	3(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-(4-(2,6-dichlorophenyl)-oxazol-2-yl)-4-oxobutyric Acid	HCID 53686139	—
Reactant	3(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-(4-(2,6-dichlorophenyl)-oxazol-2-yl)-4-hydroxybutyric Acid tert-Butyl Ester	HCID 54440848	—
Reactant	3(S)-(Allyloxycarbonyl)-amino-4-((2,6-dichloro-phenyl)oxazol-2-yl)-4-hydroxy-butyric Acid tert-Butyl Ester	HCID 69724195	—
Reactant	3(S)-(Allyloxycarbonyl)-amino-4-(6-chloro-4-fluorobenzoxazol-2-yl)-4-hydroxy-butyric Acid tert-Butyl Ester	HCID 69725844	—
Product	3(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-(6-chloro-4-fluorobenzoxazol-2-yl)-4-oxobutyric Acid	HCID 54057837	—

Reaction Steps

Compound 719 was prepared by a method similar to the method used to prepare compound 710, except compound 707 was replaced with compound 714 in the preparation of 708: 1H NMR (500 MHz, CD3OD) δ 8.70-8.54 (m), 8.48-8.35 (m), 8.34-8.08 (m), 7.98-7.87 (m), 7 .75-7.67 (m), 7.63 (m), 7.58 (m), 7.51-7.44 (m), 7.43-7.29 (m), 7.28-7.03 (m), 6.97 (m), 5.51 (m), 4.99-4.66 (m), 4.65-4.26 (m), 4.25-3.61 (m), 3.42 (m), 3.13-2.83 (m), 2.68-2.42 (m), 2.23-2.00 (m), 1.02-0.69 (m). ##STR98##

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05843904
Source dataset	uspto-grants-1998_12
ORD ID	ord-403b93931307449bb9246918135f16fd
Source note	uspto-grants-1998_12