2-Aminoindane → 3(S)-(2-((2(S)-(Benzoyl)amino-3-methylbutyryl)-(1,3-dihydroisoindol-2-yl)amino)acetylamino)-4-oxo-butyric Acid

HRID 1456675Notes

Reaction equation

HRID 1456675 reaction equation
[C:1]([NH:9][C@@H:10]([CH:32]([CH3:34])[CH3:33])[C:11]([N:13](CC1C=CC=CC=1)[CH2:14][C:15]([NH:17][C@H:18]([CH:23]=[O:24])[CH2:19][C:20]([OH:22])=[O:21])=[O:16])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1CC2C(=CC=CC=2)C1.N[N:46]1[CH2:54][C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[CH2:47]1>>[C:1]([NH:9][C@@H:10]([CH:32]([CH3:33])[CH3:34])[C:11]([N:13]([N:46]1[CH2:54][C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[CH2:47]1)[CH2:14][C:15]([NH:17][C@H:18]([CH:23]=[O:24])[CH2:19][C:20]([OH:22])=[O:21])=[O:16])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 763102-AminoindaneHCID 127356181,3-Dihydro-2H-isoindol-2-amineHCID 544052433(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-oxo-butyric Acid

Product 1

HCID 541206043(S)-(2-((2(S)-(Benzoyl)amino-3-methylbutyryl)-(1,3-dihydroisoindol-2-yl)amino)acetylamino)-4-oxo-butyric Acid

Procedure

Compound 756 was prepared by a method similar to the method used to prepare compound 724 and compound 706, except 2-aminoindane was replaced with 2-aminoisoindoline (prepared as described in Eloy, F., Moussebois, C., Bull. Soc. Chim. Belg., 68, pp. 409-421 (1959)). ##STR136##

Workup

  1. customprepared

Sources & evidence

ORD record
ord-bf7c302022864f00923a0985f670be93
Source dataset
uspto-grants-1998_12
Patent number
US05843904

Reaction notes

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