HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-chloro-3-nitrobenzoate → Methyl 4-methoxy-3-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-chloro-3-nitrobenzoate | HCID 735797 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-methoxy-3-nitrobenzoate | HCID 602104 | — |
Reaction Steps
Methyl 3-nitro-4-chlorobenzoate (COMPOUND XIII) (see above for synthesis of 4-chloro-anti-CG) (1 equivalent) is treated with sodium methoxide (1.1 equivalent) in methanol with heating to produce the methyl 3-nitro-4-methoxybenzoate (COMPOUND XIV) which is purified by column chromatography and/or crystallization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05844110 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-338e1f8ba593439d9dc45880a5dff4b4 |
| Source note | uspto-grants-1998_12 |