Acetic Acid → HCID 136342239, compound

Participants

Reaction Steps

A suspension of compound (49) (200 mg, 0.4 mmol) in 2N aq. NaOH (8 ml) is boiled under reflux for 3 h. After the solution has been neutralized with conc. AcOH, the reaction product is filtered, washed with water and dried. Colorless crystals (128 mg, 96%) are obtained after crystallizing from CH3CN. 1H-NMR ([D6 ] DMSO): δ=2.22 (m, Hα --C(2')), 2.92 (m, Hβ --C(2')), 3.52 (m, H--C(5')), 3.72 (m, H--C(4')), 4.33 (m, H--C(3')), 4.81 (t, 5'-OH), 5.22 (d, 3'-OH), 6.35 (dd, H--C(1')), 6.46 (br., NH2), 10.75 (s,NH).

Provenance & Evidence