Ammonia → HCID 10770376, compound

HRID 1456861Notes

Reaction equation

HRID 1456861 reaction equation
C[O:2][C:3](=[O:46])[CH2:4][CH2:5][C:6]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH2:34][C:35]2[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[N:36]=2)=[C:29]([Cl:45])[CH:28]=1)([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)=[C:10]([Cl:26])[CH:9]=1)[CH3:7].COC(=O)CCC(C1C=CC(OCC2C=CC3C(=CC=CC=3)N=2)=CC=1)(C1C=CC(OCC2C=CC3C(=CC=CC=3)N=2)=CC=1)C.N>O>[Cl:45][C:29]1[CH:28]=[C:27]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]=3)=[C:10]([Cl:26])[CH:9]=2)([CH3:7])[CH2:5][CH2:4][C:3]([OH:46])=[O:2])[CH:32]=[CH:31][C:30]=1[O:33][CH2:34][C:35]1[CH:44]=[CH:43][C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[N:36]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 10604293HCID 10604293, compoundHCID 10722006HCID 10722006, compound

Product 1

HCID 10770376HCID 10770376, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The desired compound was prepared according to the method of Example 1, step 3, except substituting 4,4-bis(3-chloro-4-(2-quinolylmethoxy)phenyl)pentanoic acid methyl ester, prepared as in step 1, for 4,4-bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid methyl ester: mp 91°-94° C.; 1H NMR (300 MHz, DMSO-d6) d 1.53 (s, 3H), 1.96 (m, 2H), 2,30 (m, 2H), 5.44 (s, 4H), 7.09 (dd, 2H, J=3, 9 Hz), 7.20 (d, 2H, J=9 Hz), 7.24 (d, 2H, J=3Hz), 7.62 (m, 2H), 7.71 (d, 2H, J=9 Hz), 7.80 (m, 2H), 8.00 (m, 4H), 8.44 (d, 2H, J=9 Hz), 12.08 (bs, 1H); MS (DCl--NH3) m/e 637 (M+H)+. Anal. Calc'd. for C37H30Cl2N2O4 ×H2O: C, 67.79; H, 4.92; N, 4.27. Found: C, 68.02; H, 4.85; N, 3.94.

Sources & evidence

ORD record
ord-822fe636d5214d189ea2ff7ef39a0506
Source dataset
uspto-grants-1998_12
Patent number
US05843968

Reaction notes

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