反应详情

Compound (19) is prepared by a method analogous to the one described by Shinkai et al. (1990, supra). Compound (3) is converted to the sodium salt with excess sodium hydride in a solvent such as tetrahydrofuran or dimethylformamide and then reacted 1-bromo-3-(perfluoro-tert-butyl)propane to furnish Compound (19) which is purified by crystallization or chromatography. 1-bromo-3-(perfluoro-tert-butyl)propane is prepared by reacting perfluoroisobutylene and cesium fluoride in a solvent like monoglyme with excess dibromopropane as described by Rogers et al. (1993, U.S. Pat. No. 5,234,680).

1. customis purified by crystallization or chromatography