Trifluoroacetic acid → 5-(2-Pyridyldithiomethyl)benzofuran-2-carboxylic acid

HRID 1456882노트

반응식

F[C:2](F)(F)[C:3]([OH:5])=[O:4].[N:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14][S:15][CH2:16][C:17]1[CH:18]=[CH:19][C:20]2[O:24]C(C(NC3C=C4C(=CC=3)NC(C(OC(C)(C)C)=O)=C4)=O)=[CH:22][C:21]=2[CH:44]=1>>[N:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14][S:15][CH2:16][C:17]1[CH:18]=[CH:19][C:20]2[O:24][C:2]([C:3]([OH:5])=[O:4])=[CH:22][C:21]=2[CH:44]=1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 15345486HCID 15345486, 화합물

생성물 1

HCID 153454855-(2-Pyridyldithiomethyl)benzofuran-2-carboxylic acid

실험 절차

To 4 mL trifluoroacetic acid, cooled to 0° C. and stirred under argon, was added 16 (120 mg, 0.23 mmol). After 2 h, trifluoroacetic acid was removed under reduced pressure to give 15 as an off-white solid: NMR (acetone-d6) d 4.3 (2,2H), δ7.3-8.7 (m, 12H).

후처리

customtrifluoroacetic acid was removed under reduced pressure

출처 및 근거

ORD 기록: ord-15addc1e99684c99a80939f6d19bd9ac
출처 데이터셋: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05846545

반응 노트

불러오는 중…