反应详情

温度

88 °C

Thirty mg of 4,7,10-triscarboxymethyl-1-oxa-4, 7,10-triazacyclododecane (see Example 1) was added to 0.7 ml of 100 mM gadolinium acetate. The solution was adjusted to pH 3 and heated at 88° C. for 20 minutes. A precipitate was visible when the solution was adjusted to pH 7.3. 4,7,10-Triscarboxymethyl-1-oxa-4,7,10-triazacyclododecane (16 mg) was added, the solution adjusted to pH 3 and heated at 88° C. for 20 minutes. On adjustment to pH 7.3, a slight precipitate was observed. Twenty mg of 4,7,10-triscarboxymethyl-l-oxa-4,7,10-triazacyclododecane was added and the solution was adjusted to pH 3.0. Reheating under the same conditions resulted in reducing the free gadolinium to 0.22±0.18% as measured by paper thin layer chromatography of a radiolabeled chelate solution. The final chelate solution was clear at pH 7.3. It was passed through a 0.22 μ filter (Millipore) into a vial and sealed.

1. temperatureheated at 88° C. for 20 minutes
2. customresulted
3. filtrationfilter (Millipore) into a vial and
4. customsealed