Gadolinium → HCID 19838415, compound

HRID 1456889Notes

Reaction equation

HRID 1456889 reaction equation
[C:1]([CH2:4][N:5]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][CH2:12][N:11]([CH2:21][C:22]([OH:24])=[O:23])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)([OH:3])=[O:2].C([O-])(=O)C.[Gd+3:29].C([O-])(=O)C.C([O-])(=O)C.[Gd]>>[C:1]([CH2:4][N:5]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][CH2:12][N:11]([CH2:21][C:22]([OH:24])=[O:23])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)([OH:3])=[O:2].[Gd+3:29]

Participants

4

Reactant 3

HCID 23982GadoliniumHCID 159771Acetic acid, gadolinium(3+) salt (3:1)HCID 9946216HCID 9946216, compound3×

Product 1

HCID 19838415HCID 19838415, compound

Conditions

Temperature
88 °C

Procedure

Thirty mg of 4,7,10-triscarboxymethyl-1-oxa-4, 7,10-triazacyclododecane (see Example 1) was added to 0.7 ml of 100 mM gadolinium acetate. The solution was adjusted to pH 3 and heated at 88° C. for 20 minutes. A precipitate was visible when the solution was adjusted to pH 7.3. 4,7,10-Triscarboxymethyl-1-oxa-4,7,10-triazacyclododecane (16 mg) was added, the solution adjusted to pH 3 and heated at 88° C. for 20 minutes. On adjustment to pH 7.3, a slight precipitate was observed. Twenty mg of 4,7,10-triscarboxymethyl-l-oxa-4,7,10-triazacyclododecane was added and the solution was adjusted to pH 3.0. Reheating under the same conditions resulted in reducing the free gadolinium to 0.22±0.18% as measured by paper thin layer chromatography of a radiolabeled chelate solution. The final chelate solution was clear at pH 7.3. It was passed through a 0.22 μ filter (Millipore) into a vial and sealed.

Workup

  1. temperatureheated at 88° C. for 20 minutes
  2. customresulted
  3. filtrationfilter (Millipore) into a vial and
  4. customsealed

Sources & evidence

ORD record
ord-57b978d972434fc1bd5f7eeee3bae3e2
Source dataset
uspto-grants-1998_12
Patent number
US05846519

Reaction notes

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