HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloro-2-methyl-5-nitropyrimidine → 4,6-Dichloro-2-methylpyrimidin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloro-2-methyl-5-nitropyrimidine | HCID 83192 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4,6-Dichloro-2-methylpyrimidin-5-amine | HCID 736674 | — |
Reaction Steps
The third intermediate, 4,6-dichloro-2-methyl-5-nitropyrimidine is hydrogenated over Raney-Ni as a 10% to 30% solution in toluene to afford the corresponding compound, 4,6-dichloro-2-methyl-5-aminopyrimidine, as a fourth intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05846974 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-c1b35c5e1f41455295485082231cd4ba |
| Source note | uspto-grants-1998_12 |