4-(Benzyloxy)-3-hydroxybenzonitrile → HCID 22103092, compound

HRID 1456947Notes

Reaction equation

HRID 1456947 reaction equation
CS([C:5]1[N:10]=[C:9]([O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:8]([N+:18]([O-:20])=[O:19])=[C:7]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([N:30]([CH3:32])[CH3:31])=[O:29])[CH:23]=2)[N:6]=1)(=O)=O.[CH2:33]([O:40][C:41]1[CH:46]=[CH:45][C:44]([C:47]#[N:48])=[CH:43][C:42]=1[OH:49])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH2:33]([O:40][C:41]1[CH:46]=[CH:45][C:44]([C:47]#[N:48])=[CH:43][C:42]=1[O:49][C:5]1[N:10]=[C:9]([O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:8]([N+:18]([O-:20])=[O:19])=[C:7]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([N:30]([CH3:32])[CH3:31])=[O:29])[CH:23]=2)[N:6]=1)[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 154534514-(Benzyloxy)-3-hydroxybenzonitrileHCID 22102949HCID 22102949, compound

Product 1

HCID 22103092HCID 22103092, compound

Procedure

In a similar manner, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine, a compound of formula (R), was treated with 2-benzyloxy-5-cyanophenol to yield 2-(2-benzyloxy-5-cyanophenoxy)-4-(ethoxycarbonyl)methoxy-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine, a compound of formula (S).

Sources & evidence

ORD record
ord-357266c5a9074e13ab1e5848c9444ead
Source dataset
uspto-grants-1998_12
Patent number
US05846970

Reaction notes

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