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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1456954Generated: October 25, 2026

Ethyl Glycolate → 2-Methylthio-4-(ethoxycarbonyl)methoxy-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine

https://huagongshe.com/reaction/1456954

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl GlycolateHCID 12184—
Reactant2-Methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidineHCID 22102986—
Product2-Methylthio-4-(ethoxycarbonyl)methoxy-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidineHCID 22103102—

Reaction Steps

In a similar manner, 2-methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine, a compound of formula (K), is treated with ethyl glycolate, a compound of formula (P), to yield 2-methylthio-4-(ethoxycarbonyl)methoxy-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine, a compound of formula (U).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05846972
Source datasetuspto-grants-1998_12
ORD IDord-662e78cb82814cffb3ad11e0b49bc06c
Source noteuspto-grants-1998_12