1-Methyl-4-piperidone → HCID 18797195, compound

HRID 1456974Notes

Reaction equation

HRID 1456974 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][NH:9]2)=[CH:5][CH:4]=1.[CH3:14][N:15]1[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]1>>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:18]3[CH2:19][CH2:20][N:15]([CH3:14])[CH2:16][CH:17]=3)=[CH:8][NH:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 27775236-(Trifluoromethyl)indole

Product 1

HCID 18797195HCID 18797195, compoundYield 89%

Procedure

Beginning with 1.00 gm (5.4 mMol) 6-trifluoromethyl-1H-indole and 1.33 mL (11.0 mMol) 1-methyl-4-piperidone, 1.34 gm (89%) of the title compound were recovered as colorless crystals.

Sources & evidence

ORD record
ord-68e38ed854fc4be980b57ae9ceef9a86
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

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