6-Nitro-1H-indole → HCID 21268269, compound

HRID 1456989Notes

Reaction equation

HRID 1456989 reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].O.Cl.[NH:15]1[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]1>>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([C:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH:17]=3)=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 785026-Nitro-1H-indoleHCID 2723901Piperonylamine

Product 1

HCID 21268269HCID 21268269, compoundYield 97.8%

Procedure

Beginning with 6.0 gm (37.0 mMol) 6-nitro-1H-indole and 11.4 gm (74.0 mMol) 4-piperidone hydrochloride monohydrate, 8.8 gm (97%) of the title compound were recovered as an orange solid.

Sources & evidence

ORD record
ord-2d6a3484d00943e8a1ec874b0e93d2ee
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

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