HCID 21268342, compound → HCID 18797335, compound

HRID 1457005Notes

Reaction equation

HRID 1457005 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10]3(O)[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)=[CH:7][C:6]=2[CH:24]=1>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH:11]=3)=[CH:7][C:6]=2[CH:24]=1

Participants

3

Reactant 1

HCID 21268342HCID 21268342, compound

Product 1

HCID 18797335HCID 18797335, compoundYield 65.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.998 gm (2.72 mMol) 5-chloro-2-(4-hydroxy-1-(tert-butoxycarbonyl)piperidin-4-yl)benzothiophene in 10.0 mL dichloromethane was subjected to the reaction conditions described in the previous example, providing 0.444 gm (65%) of 5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)benzothiophene as a tan solid. This material was dissolved in ethyl acetate and the solution was treated with oxalic acid. The resulting solution was concentrated under reduced pressure to give the title compound.

Sources & evidence

ORD record
ord-fcfa113d57f64271ab91c89bdd8f309b
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

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