HCID 21268219, compound → HCID 21268220, compound

HRID 1457006Notes

Reaction equation

HRID 1457006 reaction equation
[Cl:1][C:2]1[C:7]2[CH:8]=[C:9]([C:11]3(O)[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1>ClCCl>[Cl:1][C:2]1[C:7]2[CH:8]=[C:9]([C:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH:12]=3)[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 21268219HCID 21268219, compound

Product 1

HCID 21268220HCID 21268220, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.29 gm (0.79 mMol) 4-chloro-2-(4-hydroxy-1-(tert-butoxycarbonyl)piperidin-4-yl)benzothiophene in 4.0 mL dichloromethane was subjected to the reaction conditions described in Example 51, providing 0.175 gm (88%) of 4-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)benzothiophene as a tan powder.

Sources & evidence

ORD record
ord-69a8b30994e74562a9b5d79c97a22689
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

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