HCID 21866069, compound → HCID 21268229, compound

HRID 1457007Notes

Reaction equation

HRID 1457007 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[CH:6]=[C:7]([C:9]3(O)[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]3)[S:8][C:4]=2[CH:3]=1>ClCCl>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[CH:6]=[C:7]([C:9]3[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=3)[S:8][C:4]=2[CH:3]=1

Participants

3

Reactant 1

HCID 21866069HCID 21866069, compound

Product 1

HCID 21268229HCID 21268229, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.04 gm (2.83 mMol) 6-chloro-2-(4-hydroxy-1-(tert-butoxycarbonyl)piperidin-4-yl)benzothiophene in 30.0 mL dichloromethane was subjected to the reaction conditions described in Example 51, providing 0.64 gm (90%) of 6-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)benzothiophene as a tan powder.

Sources & evidence

ORD record
ord-6b1fd7fab16f4f00ba667a24407a4ae4
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

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