Trimethylsilyl iodide → HCID 18797359, compound

HRID 1457011Notes

Reaction equation

C1(C[O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:11]3[C:7]=2[C:8]([C:15]2[CH2:16][CH2:17][N:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:19][CH:20]=2)=[CH:9][NH:10]3)CC1.C[Si](I)(C)C>>[OH:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[C:8]([C:15]1[CH2:16][CH2:17][N:18]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:19][CH:20]=1)=[CH:9][NH:10]2

Participants

Reactant 2

HCID 85247Trimethylsilyl iodide

HCID 18797152HCID 18797152, compound

Product 1

HCID 18797359HCID 18797359, compoundYield 35.2%

Procedure

Following the procedure described in detail in Example 58, 1.2 gm (3.35 mMol) 4-cyclopropylmethoxy-3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole were reacted with trimethylsilyl iodide to provide 0.359 gm (35%) of the title compound as a tan solid.

Sources & evidence

ORD record: ord-09e449026d394e1c95bd48d75ed921eb
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05846982

Reaction notes

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