Acetyl chloride → HCID 15428620, compound

HRID 1457058Notes

Reaction equation

O.Cl.Cl.[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=3[C:8]=2[CH2:7]1.CN(C)C1CC[C:26]2[O:27]C3C=CC(N)=CC=3[C:25]=2C1.Cl.Cl.C(Cl)(=O)C>>[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:26](=[O:27])[CH3:25])=[CH:13][C:12]=3[C:8]=2[CH2:7]1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 69947452HCID 69947452, compound

Product 1

HCID 15428620HCID 15428620, compoundYield 77%

Procedure

Beginning with 9.0 mg (0.029 mMol) of N,N-dimethyl-8-amino-1,2,3,4-tetrahydro-2-dibenzofuranamine dihydrochloride hemihydrate and 2.8 mg (0.036 mMol) of acetyl chloride, 6.05 mg (77%) of the title compound were recovered by the procedure described in Example 2.

Sources & evidence

ORD record: ord-dc097f4a9b634d37a82f953b9e9d97dd
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05846995

Reaction notes

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