Cyclobutanecarbonyl chloride → HCID 15428622, compound

HRID 1457060Notes

Reaction equation

HRID 1457060 reaction equation
O.Cl.Cl.[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=3[C:8]=2[CH2:7]1.CN(C)C1CCC2[O:27][C:28]3[CH:33]=[CH:32][C:31](N)=[CH:30]C=3C=2C1.Cl.Cl.C1(C(Cl)=O)CCC1>>[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:28]([CH:33]4[CH2:32][CH2:31][CH2:30]4)=[O:27])=[CH:13][C:12]=3[C:8]=2[CH2:7]1

Participants

3

Reactant 2

HCID 78705Cyclobutanecarbonyl chlorideHCID 69947452HCID 69947452, compound

Product 1

HCID 15428622HCID 15428622, compoundYield 74%

Procedure

Beginning with 9.0 mg (0.029 mMol) of N,N-dimethyl-8-amino-1,2,3,4-tetrahydro-2-dibenzofuranamine dihydrochloride hemihydrate and 4.3 mg (0.036 mMol) of cyclobutanecarbonyl chloride, 6.7 mg (74%) of the title compound were recovered by the procedure described in Example 2.

Sources & evidence

ORD record
ord-1bca779c56f741c78b631f38a987ce58
Source dataset
uspto-grants-1998_12
Patent number
US05846995

Reaction notes

Loading…