HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1457139Generated: November 4, 2026
Hydrochloric Acid → Des((2-isopropylthiazol-4-yl)methyl-methyl-carbamoyl)ritonavir
https://huagongshe.com/reaction/1457139
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 12-Oxa-2,7,10-triazatetradecanoic acid, 4-hydroxy-13,13-dimethyl-9-(1-methylethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, [3S-(3R*,4R*,6R*,9R*)]- | HCID 22863037 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Des((2-isopropylthiazol-4-yl)methyl-methyl-carbamoyl)ritonavir | HCID 22863038 | — |
Reaction Steps
A solution of 0.1 mmol of the resultant compound of Example 31 E was treated with 10 ml of 4N HCl in dioxane, stirred at 0° C. for 1 h, concentrated in vacuo, partitioned between chloroform and aqueous NaHCO3, dried over Na2SO4, and concentrated to provide the crude desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05846987 |
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| Source dataset | uspto-grants-1998_12 |
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| ORD ID | ord-5fd66887740b4f9db2387c3bf27dc80f |
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| Source note | uspto-grants-1998_12 |
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