Sodium Iodide → HCID 10907333, compound

Participants

Reaction Steps

To a solution of the title compound of Step (D) (45 mg, 0.075 mmol) in 3 ml of CH3CN, Me3SiCl (41 mg, 0.38 mmol) was added and followed by NaI (57 mg, 0.38 mmol). The mixture was stirred at room temperature for 1.5 hrs. Additional Me3SiCl (32 mg, 0.3 mmol) and NaI (46 mg, 0.3 mmol) were added in twice after stirred for 30 min and 1 hr. 3 ml H2 O and 30 ml EtOAc were added. The organic layer was washed with sat. Na2S2O3, brine, dried and concentrated. The residue was purified by preparative HPLC on an ODS S10 column using 33% solvent A (10% MeOH, 90% H2O, 0.1% TFA) and 67% solvent B (90% MeOH, 10% H2O, 0.1% TFA) to provide the title compound of this Example (23 mg, 60%) as a white solid, m.p. 117°-123° C. (amorphous).

Provenance & Evidence